CALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Force maintenance and myosin filament assembly regulated by Rho-kinase in airway smooth muscle
نویسندگان
چکیده
Bo Lan,* Linhong Deng,* Graham M. Donovan, Leslie Y. M. Chin, Harley T. Syyong, Lu Wang, Jenny Zhang, Christopher D. Pascoe, Brandon A. Norris, Jeffrey C.-Y. Liu, Nicholas E. Swyngedouw, Saleha M. Banaem, Peter D. Paré, and Chun Y. Seow Bioengineering College, Chongqing University, Chongqing, China; Department of Mathematics, University of Auckland, Auckland, New Zealand; Department of Medicine, University of British Columbia, Vancouver, Canada; Vancouver, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, China; and Centre for Heart Lung Innovation, St Paul’s Hospital, University of British Columbia, Vancouver, Canada
منابع مشابه
Force maintenance and myosin filament assembly regulated by Rho-kinase in airway smooth muscle.
Smooth muscle contraction can be divided into two phases: the initial contraction determines the amount of developed force and the second phase determines how well the force is maintained. The initial phase is primarily due to activation of actomyosin interaction and is relatively well understood, whereas the second phase remains poorly understood. Force maintenance in the sustained phase can b...
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متن کاملNonmuscle myosin is regulated during smooth muscle contraction.
The participation of nonmuscle myosin in force maintenance is controversial. Furthermore, its regulation is difficult to examine in a cellular context, as the light chains of smooth muscle and nonmuscle myosin comigrate under native and denaturing electrophoresis techniques. Therefore, the regulatory light chains of smooth muscle myosin (SM-RLC) and nonmuscle myosin (NM-RLC) were purified, and ...
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